甘草酸单铵盐 T6384

Product Introduction
Bioactivity


英文名: Ammonium Glycyrrhizinate

描述: Ammonium Glycyrrhizinate (Glycyram) 抑制几种不相关的 DNA/RNA 病毒的细胞病理学和生长。

体外活性: Ammonium glycyrrhizinate (AG) markedly protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also dose-dependently inhibits FeSO(4)-induced reactive oxygen radicals.

体内活性: Ammonium glycyrrhizinate down-regulates the TNF-α level and up-regulates IL-10 level and inhibits the cAMP-PDE activity in the lung tissue of mice. Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate increases HDL levels in rats. Ammonium glycyrrhizinate significantly decreases cholesterol, triglyceride, LDL and very VLDL levels in rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 155 mg/mL (184.5 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 5 mg/mL (5.95 mM)


关键字: Ammonium Glycyrrhizinate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途