化合物Linvencorvir T64221

Product Introduction
Bioactivity


英文名: Linvencorvir

描述: Linvencorvir 是一种乙型肝炎病毒（HBV）核心蛋白变构调节剂，用于治疗慢性HBV 感染。

体内活性: Linvencorvir (RO7049389) (600/1000 mg; oral; Caucasian and Asian, male and female) followed by 100 μg intravenous [13 C]RO7049389. The model performance in predicting the pharmacokinetic profiles of RO7049389 aligned with clinical observations in Caucasians and was also successfully applied to Asians. Accordingly, the drug disposition pathways for RO7049389 were postulated with newly characterized estimates of the fractions: biliary excretion by P-glycoprotein (~41%), direct glucuronidation via uridine 5'-diphosphoglucuronosyltransferase 1A3 (~11%), hexose conjugation (~6%), oxidation by CYP3A4 (~28%) and other oxidation reactions (~9%). These results support the ongoing clinical development program for RO7049389 and highlight the broader value of PBPK and MB analyses in drug development.[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 56.2 mg/mL (94.0 mM)


关键字: Linvencorvir | RG-7907 | RG 7907

相关产品: Herpetone | Coclauril | 4,5-Dihydroblumenol A | Lagociclovir | Osthole | Merimepodib | HBV-IN-36 | Ibandronic acid | Swertianolin | HBV-IN-35

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途