化合物QN523u00A0 T64374

Product Introduction
Bioactivity


英文名: QN523 

描述: QN523是一种具有类药物性质的新型支架，在12个癌症细胞系中显示出强大的体外细胞毒性。QN523在胰腺癌症异种移植模型中显示出显著的体内疗效。自噬是QN523发挥作用的主要机制。

体外活性: QN523 showed significant cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines. QN523 at 0.5 μM and gemcitabine at 0.1 μM arrested MIA PaCa-2 cells in the S-phase following 24 and 48 h treatment[1].

体内活性: In NOD/SCID mice of MIA PaCa-2 xenografts, QN523 at 10 mg/kg (intraperitoneal administration) shows no significant delay in tumor growth from day 1 to day 9. QN523 at 20 mg/kg from day 10 and continued until day 44 delayed growth of the MIA PaCa-2 xenograft starting from day 17. On day 44 80% inhibition of tumor growth was observed. No symptoms of gross toxicity such as weakness, weight loss or lethargy were observed in the QN523 treatment group[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.2mg/mL (64.7mM)


关键字: QN-523 | QN523 | QN523  | QN 523

相关产品: Polydatin | MHY1485 | Clofarabine | Memantine hydrochloride | LX2343 | LY2183240 | Matrine | Apigenin | Zebularine | Azithromycin hydrate

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Autophagy Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途