化合物MDL-800 T64529

Product Introduction
Bioactivity


英文名: MDL-800

描述: SIRT6, responsible for deacetylation of histone H3 Nε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac), is a tumor suppressor which has frequently been found to have low expression in various cancers. MDL-800 is a selective SIRT6 activator. It increased the deacetylase activity of SIRT6 by up to 22-fold and led to a global decrease in H3K9ac and H3K56ac levels in human hepatocellular carcinoma (HCC) cells. Also, it inhibited the proliferation of HCC cells via SIRT6-driven cell-cycle arrest and was effective in a tumor xenograft model.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 62.63 mg/mL (100 mM)


关键字: MDL-800

相关产品: MIND4-19 | OSS_128167 | Nicotinamide riboside | SIRT-IN-2 | SRT 2104 | 5-Feruloylquinic acid | Agrimol B | SRT1720 hydrochloride | Epigenetic factor-IN-1 | Suramin Sodium Salt

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Histone Modification Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途