雌马酚 T6491
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 531-95-3 | ¥578.00 | 询底价 |
1 mg | 531-95-3 | ¥185.00 | 询底价 |
50 mg | 531-95-3 | ¥1,730.00 | 询底价 |
500 mg | 531-95-3 | ¥5,930.00 | 询底价 |
100 mg | 531-95-3 | ¥2,580.00 | 询底价 |
1 mL | 531-95-3 | ¥455.00 | 询底价 |
5 mg | 531-95-3 | ¥413.00 | 询底价 |
25 mg | 531-95-3 | ¥970.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (-)-(S)-Equol
描述: (-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。
细胞实验: Each well of a 24-well plate is seeded with 1 × 105 MCF-7 cells in 1 mL of media B. Twenty-four hours after plating, equol at the indicated concentration is added. Equol is dissolved in ethanol (final concentration of ethanol in the medium is 1%). The medium is changed every 24 hours and equol is replenished with each change. Cell growth is determined on the sixth day by the sulphorhodamine colorimetric assay. After colour development, aliquots are pipetted into a 96-well microtitre plate and the absorbance is determined at 570 nm using an Elisa microplate reader.(Only for Reference)
体外活性: Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a Ki of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a Ki of 50 nM. [1] Equol is superior to all other isoflavones in its antioxidant activity. [2] Equol has antioestrogenic properties. [3] Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with 3 H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression. [4]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (185.74 mM)
Ethanol : 24.2 mg/mL (100 mM)
关键字: Inhibitor | inhibit | Endogenous Metabolite | Estrogen Receptor/ERR | ( ) (S) Equol | ()(S)Equol
相关产品: Estetrol | Brilanestrant | Erteberel | Etonogestrel | Propyl pyrazole triol | GSK5182 | Clomiphene citrate | Acolbifene | Estriol | Tracheloside
相关库: Anti-Neurodegenerative Disease Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Endocrinology-Hormone Compound Library | RO5 Drug-like Natural Product Library | Anti-Alzheimer's Disease Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途