乙基双亚氨基甲基愈创木酚锰氯化物 T6495

Product Introduction
Bioactivity


英文名: EUK-134

描述: EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。

体外活性: EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4]

体内活性: EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 77 mg/mL (184.8 mM)
H2O : 11 mg/mL (26.4 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: Inhibitor | Free | mitoprotective | Nephrotoxicity | antioxidant | SODm | species | Nuclear factor-kappaB | NRK-52E | EUK-134 | radicals | NF-κB | inhibit | oxygen | Nuclear factor-κB | catalase | Reactive | EUK134 | Superoxide | mimetic | SOD | dismutase

相关产品: BMS 433796 | δ-secretase inhibitor 11 | Ginsenoside Rg1 | Amyloid β Peptide (42-1)(human) acetate | β-Amyrin | Lecanemab | Hederacolchiside E | Itanapraced | Isorosmanol | V-9-M Cholecystokinin nonapeptide

相关库: Antioxidant Compound Library | Anti-Neurodegenerative Disease Compound Library | Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Ferroptosis Compound Library | Inhibitor Library | Cuproptosis Compound Library | Preclinical Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途