卤倍他索丙酸酯 T6529

Product Introduction
Bioactivity


英文名: Halobetasol propionate

描述: Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。

体外活性: Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 36 mg/mL (74.2 mM)
DMSO : 90 mg/mL (185.6 mM)


关键字: Inhibitor | BMY30056 | BMY 30056 | Ulobetasol Propionate | Halobetasol (propionate) | CGP14458 | inhibit | CGP 14458

相关产品: ML299 | 9-Oxononanoic Acid | trans-Benzylideneacetone | Fuzapladib | BIRM 271 | Amentoflavone | A4333 | Ecopladib | 5-HT1A modulator 1 | CCT129957

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Bioactive Lipid Compound Library | Fluorochemical Library | Inhibitor Library | Anti-Obesity Compound Library | Anti-Fibrosis Compound Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途