左氧氟沙星 T6567

Product Introduction
Bioactivity


英文名: Levofloxacin

描述: Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素，有抑制细菌DNA 旋转酶的超螺旋活性的作用，能阻止DNA 复制。

体外活性: Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate?activity?against anaerobes.[1] Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more?active?than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.?Levofloxacin?inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. [2] Levofloxacin?exhibits twofold greater?inhibitory?and?bactericidal?activities?than ofloxacin?against?either extracellular or intracellular tubercle bacilli.?[3] Levofloxacin?has the least?inhibitory?effect on osteoblastic cell growth, with a 50%?inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis.[4] Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. [5]

体内活性: Levofloxacin 在小鼠的全身性及肾盂肾炎感染中，其疗效相当于或优于环丙沙星。Levofloxacin 在小鼠的血清和组织中达到的浓度高于环丙沙星。[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12.5 mg/mL (34.59 mM)
Ethanol : 2 mg/mL(5.5 mM)
H2O : 9 mg/mL (24.9 mM)


关键字: Orthopoxvirus | BK Viremia | Topoisomerase | inhibit | Inhibitor | Levofloxacin | Antibiotic | DNA gyrase | airway inflammation | DNA/RNA Synthesis | Bacterial | Ofloxacin | chronic periodontitis

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相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | RO5 Drug-like Natural Product Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途