南昌霉素 T6601

Product Introduction
Bioactivity


英文名: Nanchangmycin

描述: Nanchangmycin (Nanchangmycin A) 由 Streptomyces nanchangensis 产生的一种聚醚抗生素，抑制革兰氏阳性菌。它也是一种广谱抗病毒药物，有抗 Zika 病毒作用。

细胞实验: 5×10E3 U2OS cells were plated in 25ul media per well in 384-well plates and cultured for 24 hours. Add 50 nl of Nanchangmycin, which is 0.7uM dissolved in 0.2% DMSO, to each well incubating for 1 hour.

激酶实验: Histone deacetylase activity:For PCI-34051 characterization, measurements are performed in a reaction volume of 100 μL using 96-well assay plates in a fluorescence plate reader. For each isozyme. The HDAC protein in reaction buffer (50 mM HEPES, 100 mM KCl, 0.001% Tween-20, 5% dimethyl sulfoxide, pH7.4, supplemented with bovine serum albumin at concentrations of 0-0.05%) is mixed with PCI-34051 at various concentrations and allowed to incubate for 15 min. Trypsin is added to a final concentration of 50 nM, and acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methyl coumarin is added to a final concentration of 25-100 μM to initiate the reaction. After a 30 min lag time, the fluorescence is measured over a 30 min time frame using an excitation wavelength of 335 nm and a detection wavelength of 460 nm. The increase in fluorescence with time is used as the measure of the reaction rate.

体外活性: Nanchangmycin对抗革兰氏阳性细菌。

体内活性: Nanchangmycin，作为家禽生长促进剂，有效治疗鸡的球虫病。作为一种细菌来源的天然产物，Nanchangmycin在多种细胞类型中强效阻断ZIKV和DENV感染。

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 88.9 mg/mL (100 mM)


关键字: Inhibitor | Antibiotic | inhibit | Bacterial | Nanchangmycin

相关产品: Fusidic acid sodium salt | Lapachol | Camalexin | Tildipirosin | Narirutin | Isoeugenol | PK150 | Glycitin | Florfenicol | 3,4-Dihydroxy-2-methoxyxanthone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途