化合物RG2833 T6639

Product Introduction
Bioactivity


英文名: RG2833

描述: RG2833 (RGFP109) 是一种脑渗透性 HDAC 抑制剂，对 HDAC1 和 HDAC3 的 IC50 分别为 60 nM 和 50 nM，Ki 值分别为 32 和 5 nM。

激酶实验: Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit.

体外活性: In unstimulated peripheral blood mononuclear cells, RG2833 upregulates the level of the synaptic mRNA and protein in a dose-dependent manner.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 63 mg/mL (185.6 mM)
Ethanol : 10 mg/mL (29.46 mM)


关键字: RGFP-109 | RG2833 | Inhibitor | RG 2833 | HDAC | inhibit | RGFP 109 | Histone deacetylases | RG-2833

相关产品: Raddeanin A | HDAC6 degrader 9c | Tubastatin A | Pyroxamide | HDAC-IN-7 | HDAC-IN-60 | HDAC-IN-59 | Bufexamac | UF010 | BRD4097

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Preclinical Compound Library | Chromatin Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途