沙芬酰胺甲磺酸盐 T6651

Product Introduction
Bioactivity


英文名: Safinamide mesylate

描述: Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂，对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用，可用于研究帕金森病、缺血脑卒中等疾病。

动物实验: Animal Models: DA-depleted C57BL miceFormulation: sterile 0.9% sodium chloride solutionDosages: 20 mg/kgAdministration: Inject intraperitoneally in a single dose

体外活性: Safinamide is a highly specific MAO-B inhibitor in rat brain mitochondria (IC50: 98 nM) and also inhibits MAO-B in human brain (IC50: 9 nM). Safinamide has a high affinity for the Na+ channel-binding site II in rat cortical membranes (IC50: 8 μM). Safinamide concentration- and state-dependently inhibits the fast Na+ currents in rat cortical neurons. Safinamide blocks N-Type Ca2+ currents in rat cortical neurons (IC50: 23 μM). Safinamide inhibits glutamate release induced by depolarizing conditions in rat hippocampal synaptosomes (IC50: 9 μM). Safinamide ( IC50: 1.4 μM) incubated 1 hour before veratridine reduces the neuron damage through blockade of opening voltage-dependent Na+ and Ca2+ channels in rat primary cortical neurons. Safinamide binds to human MAO-B (Ki: 0.5 μM). Safinamide binds to human MAO-B in an extended conformation occupying both flavin and entrance cavity.

体内活性: Safinamide (p.o.) dose-dependently inhibits mouse brain MAO-B (IC50: 0.6 mg/kg), and MAO-B activity recovers quickly, starting from 8 hours. Safinamide markedly inhibits cell body degeneration in the substantia nigra pars compacta. Safinamide intraperitoneally administered 15 minutes before kainic acid protects against hippocampal neuron loss, starting at 10 mg/kg showing neuroprotective properties. Safinamide (100 mg/kg, i.p.) shows a relevant neuro rescuing effect on hippocampal neurons when given 3 hours after ischemia. Safinamide has a high oral bioavailability (80-92%), is rapidly absorbed in plasma after reaching the peak within 0.5-2 hours declines, with a terminal half-life of about 3, 7, and 13 hours in mice, rats, and monkeys, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 11 mg/mL (27.6 mM)
DMSO : 74 mg/mL (185.7 mM)
H2O : 73 mg/mL (183.2 mM)


关键字: EMD 1195686 | Monoamine Oxidase | EMD-1195686 | EMD1195686 Mesylate | neuroprotective | EMD-1195686 Mesylate | NW 1015 | inhibit | OGD/R | NW1015 | Glucose | neurorescuing | Safinamide | Safinamide mesylate | anticonvulsant | MAO | PNU-151774E,FCE-28073 | deprivation/reperfusion | FCE-26743 | Safinamide Mesylate | FCE 26743 | Parkinson | PNU-151774E,FCE 28073 | α-aminoamide derivative | EMD1195686 | Stroke | FCE26743 | EMD 1195686 Mesylate | Inhibitor

相关产品: Rasagiline | 2'-O-Methylperlatolic acid | Tetrindole mesylate | Tedizolid | Nialamide | Paeonol | Tyramine | Ro 41-1049 hydrochloride | Rosmarinic acid | Echitovenidine

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | ReFRAME Related Library | Drug-induced Liver Injury (DILI) Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Highly Selective Inhibitor Library | EMA Approved Drug Library | Target-Focused Phenotypic Screening Library

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