舒洛芬 T6687

Product Introduction
Bioactivity


英文名: Suprofen

描述: Suprofen (Suprol) 是一种非甾体抗炎化合物，对前列腺素合成具有抑制作用。

体外活性: Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]

体内活性: Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. [5] Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. [6] Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization. [7]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 48 mg/mL(184.4 mM)


关键字: inhibit | TN 762 | Suprofen | TN762 | Prostaglandin E synthase | PGE synthase | Inhibitor

相关产品: 6-Acetamidohexanoic acid | Olsalazine disodium | Dexketoprofen trometamol | (R)-Naproxen | MK-886 | Celecoxib | Canolol | Tinoridine hydrochloride | Coronarin D | γ-Tocopherol

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Pyroptosis Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Approved Drug Library | NO PAINS Compound Library | Bioactive Compound Library

舒洛芬 T6687信息由TargetMol中国为您提供，如您想了解更多关于舒洛芬 T6687报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途