化合物Voreloxin T6724

Product Introduction
Bioactivity


英文名: Voreloxin

描述: Voreloxin (SNS-595) 是一种新型拓扑异构酶 II 抑制剂，具有广谱抗肿瘤活性。

体外活性: Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (49.82 mM)
H2O : <1 mg/mL
Ethanol : <1 mg/mL


关键字: Topoisomerase | SNS 595 | inhibit | Apoptosis | AG-7352 | Inhibitor | Voreloxin | SNS595 | AG7352

相关产品: 4-Hydroxybenzyl alcohol | Fedratinib hydrochloride hydrate | HPOB | HYPOCRELLIN B | KH16 | ONC212 | Piperlongumine | Dauricine | Gliotoxin | Domatinostat tosylate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途