化合物Z-FA-FMK T6738

Product Introduction
Bioactivity


英文名: Z-FA-FMK

描述: Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒蛋白酶3CL，Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶，也可以抑制效应半胱天冬酶。

细胞实验: T cell proliferation following mitogen stimulation is determined using [3H]thymidine incorporation. In brief, PBMCs or purified T cells are seeded in a 96-well plate and stimulated with either PHA (5 μg/ml), costimulated with anti-CD3 mAb (5 μg/ml) and anti-CD28 mAb (2.5 μg/ml) or PMA plus ionomycin in the presence or absence of z-FA-FMK. The cells are cultured for 72 h with the last 16 h pulsed with [methyl-3H]thymidine (0.037 MBq). The cells are harvested onto glass fiber filter mats using a Tomtec automated multiwell harvester. (Only for Reference)

体外活性: Z-FA-FMK可阻断重症综合性免疫缺陷小鼠体内Ras致癌肿瘤和宿主心脏组织的呼吸道病毒感染.在鼻内肺炎球菌感染的小鼠模型中,Z-FA-FMK可使肺和血液中肺炎球菌的生长显著增加.

体内活性: Z-FA-FMK可有效阻断体外实验中IL-2和分裂原诱导的T细胞增殖。通过成纤维细胞和破骨细胞,Z-FA-FMK可抑制纤维状胶原的降解。 Z-FA-FMK可抑制巨噬细胞中NF-κB依赖性基因的表达,从而抑制脂多糖诱导的细胞因子的产生。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 71 mg/mL (183.7 mM)
Ethanol : 32 mg/mL (82.8 mM)


关键字: SARS coronavirus | SARS-CoV | RRMs | DNA fragmentation | DEVDase | Caspase | Cathepsin | Inhibitor | externalization of phosphatidylserine | Apoptosis | inhibit | Z FA FMK | reovirus replication | Z-FA-FMK | ZFAFMK

相关产品: Acryl42-10 | SARS-CoV-2-IN-64 | Lopinavir | Arbemnifosbuvir | Chloroquine phosphate | WU-04 | Glecaprevir | GNF-2 | MTase-IN-1 | Simeprevir

相关库: Bioactive Compounds Library Max | Fluorochemical Library | Human Metabolite Library | Inhibitor Library | Highly Selective Inhibitor Library | Apoptosis Compound Library | Target-Focused Phenotypic Screening Library | Protease Inhibitor Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途