化合物ATI-2341 acetate T6764L

Product Introduction
Bioactivity


英文名: ATI-2341 acetate(1337878-62-2 free base)

描述: ATI-2341 acetate(1337878-62-2 free base) 是一种有效的 CXCR4 变构激动剂，它激活 Gα1 而不是 Gα13。 ATI-2341 acetate 激活抑制性异源三聚体 G 蛋白 (GI) 以促进对 cAMP 产生的抑制并诱导钙动员。

体外活性: ATI-2341 induced CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells[1].

体内活性: ATI-2341 induced dose-dependent peritoneal recruitment of PMNs when administered i.p. to mice. When administered systemically by i.v. bolus, ATI-2341 acted as a functional antagonist and dose-dependently mediated release of PMNs from the bone marrow of both mice and cynomolgus monkeys[1].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: ATI-2341 acetate(1337878-62-2 free base) | ATI2341 acetate(1337878622 free base) | ATI 2341 acetate(1337878 62 2 free base)

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相关库: Cytokine Inhibitor Library | Peptide Compound Library | Chemokine Inhibitor Library | Autophagy Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途