化合物 ALK/ROS1 inhibitor 2e HCL T67699L

Product Introduction
Bioactivity


英文名: ALK/ROS1 inhibitor 2e HCL

描述: ALK/ROS1 inhibitor 2e HCL 具有抗凋亡、抗增殖和抗肿瘤活性。

体外活性: (R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide (2e) showed impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M with an IC50 value of 41.3 nM.[1] 2e also showed potent inhibitory activity in about 6-fold superior to Crizotinib (IC50: 104.7 nM vs. 643.5 nM) in Ba/F3 cell line harboring ROS1G2032R.[1]

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (80.5 mM)


关键字: ALK/ROS1 inhibitor 2e HCL

相关产品: SC-236 | PD173955 | Tubastatin A | JTE-013 | DCZ0415 | FX1 | Ginsenoside Rh2 | Diethyl phthalate | PluriSIn 1 | Anisomycin

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Bioactive Compound Library

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