酪磷素AG 538 T67707

Product Introduction
Bioactivity


英文名: Tyrphostin AG 538

描述: Tyrphostin AG 538 是一种查尔酮化合物，是一种IGF-1受体激酶抑制剂（IC₅0 ：为400 nM），具有有效性、细胞渗透性、可逆性和竞争性。

体外活性: Experimentally it is indeed found that AG 538 does not compete with ATP but competes with the IGF-1R substrate. Both AG 538 and I-OMe AG 538 inhibit IGR-1R autophosphorylation in intact cells in a dose-dependent manner. Both compounds inhibit the activation of the downstream targets PKB and Erk2.[1]

体内活性: Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. FP-based assay was chosen to screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds that inhibit NS3-DNA complex formation. Four LOPAC compounds inhibited the FP-based assay: aurintricarboxylic acid (ATA) (IC50=1.4 μM), suramin sodium salt (IC50=3.6 μM), NF 023 hydrate (IC50=6.2 μM) and tyrphostin AG 538 (IC50=3.6 μM).[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.5 mg/mL (10.5 mM)


关键字: AG-538 | Tyrphostin AG 538 | AG538 | Tyrphostin AG538 | Tyrphostin AG-538

相关产品: MID-1 | Ceritinib dihydrochloride | Ceritinib | PQ401 | SU4984 | Xentuzumab | AGL-2263 | BMS-754807 | KW-2450 free base | Teprotumumab

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途