化合物AT-533 T67836

Product Introduction
Bioactivity


英文名: AT-533

描述: AT-533 是有效的 HSV 和 Hsp90 抑制剂。AT-533 可以阻断 HIF-1α/VEGF/VEGFR-2 信号通路，从而抑制血管生成和肿瘤生长。AT-533 也抑制下游通路的激活，包括 Erk1/2, FAK, Akt/mTOR/p70S6K。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的细胞迁移、侵袭和管形成。

体外活性: AT-533 (0-1350 nM; 24h or 48h) inhibits 20ng/mL VEGF induced tube formation, cell migration and HUVEC invasion. AT-533 (2 μ M or 75 μ M; 24 h) inhibits HIF-1 α/ VEGF in hypoxia induced breast cancer cells signaling pathway and inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK phosphorylation. AT-533 (10 nM, 50 nM; 48 h) exhibits anti angiogenic ability on the chorionic villus (CAM) model [1]. AT-533 (0.5 μ M; 2 hours, 4 hours) reduces TNF induced by HSV-1 in RAW264.7 and BV2 cells- α、 IL-1 β and the production of IL-6 [2].

体内活性: AT-533 (10 mg/kg; intraperitoneal injection; once a day for 21 days) inhibited the expression of HIF-1 α/ VEGF signaling pathway related proteins in mouse MDA-MB-231 xenograft model of breast cancer [1]. AT-533 (1, 2, 4 mg/kg; intraperitoneal injection; once a day for 30 days) did not cause death, appetite loss, weight loss, or adverse reactions in subacute toxicity tests of Sprague Dawley rats [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30.0 mg/mL (73.1 mM)


关键字: AT 533 | AT533 | Benzamide,2[(trans4hydroxycyclohexyl)amino]4(4,5,6,7tetrahydro3,6,6trimethyl4oxo1Hindazol1yl) | AT-533

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相关库: Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Exosome Compound Library | Anti-Viral Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途