化合物HG106 T67839

Product Introduction
Bioactivity


英文名: HG106

描述: HG106具有抗炎作用，可用于治疗由 RAS 基因突变引起的各种恶性肿瘤等疾病的生长。

体外活性: We identified a potent SLC7A11 inhibitor, HG106, that markedly decreased cystine uptake and intracellular glutathione biosynthesis. Furthermore, HG106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. [1]

体内活性: Treatment of KRAS-mutant LUAD with HG106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
Ethanol : Insoluble
DMSO : 18.9 mg/mL (59.7 mM)


关键字: Acetamide,2chloroN[2(4methoxyphenyl)2Hbenzotriazol5yl] | HG-106 | HG 106 | HG106

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途