化合物AKR1C3-IN-9 T67846
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | 价格 | 操作 |
---|---|---|
5 mg | ¥663.00 | 询底价 |
100 mg | ¥4,880.00 | 询底价 |
25 mg | ¥1,980.00 | 询底价 |
10 mg | ¥987.00 | 询底价 |
500 mg | ¥9,870.00 | 询底价 |
1 mg | ¥283.00 | 询底价 |
50 mg | ¥3,320.00 | 询底价 |
1 mL | ¥728.00 | 询底价 |
Product Introduction
Bioactivity
英文名: AKR1C3-IN-9
描述: AKR1C3-IN-9 是选择性的醛酮还原酶 1C3 (AKR1C3) 抑制剂 (IC50= 8.92 nM)。AKR1C3-IN-9 显著逆转在耐药乳腺癌细胞系对 Doxorubicin (DOX) 耐药性。
体外活性: AKR1C3-IN-9 (compound 24) (10-100 μ M; 72 h and 96 h) exhibits weak anti proliferation effect on three breast cancer cell lines (MDA-MB-231, MCF-7) with the inhibition range of 100 μ M. AKR1C3-IN-9 (10 μ M, 25 μ M, 50 μ M; 72 hours) and 10-50 μ M DOX synergistically inhibits the proliferation of MCF-7 cells. AKR1C3-IN-9 (10 μ M; 8 d) and 50 μ M DOX synergistically inhibits the proliferation and clonal survival of MCF-7/DOX cell lines, thereby restoring sensitivity to DOX [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 75.0 mg/mL (212.8 mM)
相关产品: Quercetin-3-O-glucose-6''-acetate | 2-HBA | Setanaxib | Resveratrol | ASP-9521 | GSK2795039 | Diphenyleneiodonium chloride | S19-1035 | Acetohexamide | VAS2870
相关库: Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途