LSD抑制剂24 T67871

Product Introduction
Bioactivity


英文名: LSD1-IN-24

描述: LSD1-IN-24 是一种具有选择性和有效性的 LSD1 抑制剂，IC50 值为 0.247 μM。LSD1-IN-24 可诱导 PD-L1 的表达，加强 T 细胞杀伤反应，可用于癌症相关疾病。

体外活性: LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3[1].

体内活性: In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (160.04 mM)


关键字: LSD1IN24

相关产品: KDM5-IN-1 | CP2 | KDM4C-IN-1 | Kgp-IN-1 | KDM2A/7A-IN-1 | JQKD82 trihydrochloride | GSK J5 | 5-Hydroxy-7-acetoxy-8-methoxyflavone | LSD1-IN-27 | KDM5A-IN-1

相关库: Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途