化合物BAY-069 T67927

Product Introduction
Bioactivity


英文名: BAY-069

描述: BAY-069 是一种抑制剂。BAY-069对支链氨基酸转氨酶 1 (BCAT1）具有抑制作用（IC50：31 nM ，对支链氨基酸转氨酶 2 （BCAT2) 具有抑制作用（IC50 ：153 nM）。BAY-069 是一种新型(三氟甲基)嘧啶二酮类化学探针， 可用于抗癌研究。

体外活性: BAY-069, inhibits the proliferation of U-87 and MDA-MB-231 cells. The compound is tested at concentrations ranging from 70 nM to 50 μM, with a duration of 72 hours. In U-87 cells, the IC50 is determined to be 358 nM, while in MDA-MB-231 cells, the IC50 is 874 nM [1].

体内活性: BAY-069 demonstrates high metabolic stability when incubated with human liver microsomes, with a blood clearance of 0.11 L/h/kg. It also shows moderate metabolic stability when incubated with rat hepatocytes, with a blood clearance of 1.8 L/h/kg. BAY-069 exhibits high permeability through Caco-2 cell monolayers without any signs of efflux [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (61.55 mM)


关键字: BAY 069 | BAY069 | BAY-069

相关产品: Ziyuglycoside II | Nitisinone | Glabridin | Sodium dichloroacetate | Argininosuccinic acid disodium | Riboflavin Tetrabutyrate | Mito-LND | Cobalt protoporphyrin IX | Hexahydrocurcumin | (20S)-Protopanaxadiol

相关库: Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途