那罗帕西 T68002
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 120819-70-7 | ¥5,350.00 | 询底价 |
1 mg | 120819-70-7 | ¥2,200.00 | 询底价 |
500 mg | 120819-70-7 | ¥39,700.00 | 询底价 |
50 mg | 120819-70-7 | ¥14,800.00 | 询底价 |
25 mg | 120819-70-7 | ¥10,900.00 | 询底价 |
100 mg | 120819-70-7 | ¥19,800.00 | 询底价 |
10 mg | 120819-70-7 | ¥7,530.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Naroparcil
描述: Naroparcil 是一种可口服的硫代苷类化合物,是一种 4-甲基伞形 β-D-木糖苷类似物,在静脉血栓形成(颈静脉)的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成,诱导了处理兔血浆中硫酸皮肤素样物质的出现,但减少了与(125I)-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
体内活性: Naroparcil attenuated thrombus development in a Wessler stasis model of venous thrombosis (jugular vein) employing bovine factor Xa as a thrombogenic stimulus giving ED50 values of 21.9 mg/kg and 36.0 mg/kg after respectively i.v. and p.o.. Venous antithrombotic activity was maximal 2-3 h after i.v. administration and 4-8 h after oral administration. Four hours after the oral administration of maximal antithrombotic (Wessler model, factor Xa) doses (100 and 400 mg/kg), naroparcil had no significant effect on bleeding time. In platelet-poor plasma obtained from animals treated 4 h previously with various doses (25 to 400 mg/kg) of naroparcil, there was no detectable anti-factor Xa nor antithrombin activity. Similarly, naroparcil had no effect on APTT nor on thrombin time. A sensitized thrombin time (to about 35 s) was modestly but significantly increased following oral administration of the compound at 400 mg/kg. However, thrombin generation by the intrinsic pathway was reduced in a dose-related manner, with maximal reduction being 65% at 400 mg/kg. The same dose of naroparcil enhanced the formation of thrombin/heparin cofactor II complexes at the expense of thrombin/antithrombin III complexes in plasma incubated with (125I)-human alpha-thrombin and induced the appearance of dermatan sulfate-like material in the plasma of treated rabbits, as measured by a heparin cofactor II-mediated thrombin inhibition assay.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (129.04 mM)
相关产品: Pirodomast | Bivalirudin | Thrombin receptor peptide ligand | Proflavine Hemisulfate | Dabigatran Etexilate Mesylate | Ozagrel | Flovagatran | Efegatran sulfate | Z-Gly-Pro-Arg-4MβNA | Protamine sulfate
相关库: Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途