昂唑司特 T68119
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 147432-77-7 | ¥7,380.00 | 询底价 |
500 mg | 147432-77-7 | ¥14,700.00 | 询底价 |
50 mg | 147432-77-7 | ¥5,220.00 | 询底价 |
5 mg | 147432-77-7 | ¥1,430.00 | 询底价 |
25 mg | 147432-77-7 | ¥3,620.00 | 询底价 |
1 mg | 147432-77-7 | ¥600.00 | 询底价 |
10 mg | 147432-77-7 | ¥2,130.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ontazolast
描述: Ontazolast 是一种小分子白三烯B4受体(LTB4R)拮抗剂,可用于治疗免疫系统疾病和呼吸系统疾病。Ontazolast 是治疗哮喘的候选化合物。
体内活性: Ontazolast is a potent inhibitor (IC50 = 1 nM) of calcium ionophore A23187-stimulated leukotriene B4 (LTB4) biosynthesis in human peripheral blood leukocytes. The emulsion formulation and three additional lipid-based formulations were administered by gavage to conscious, minimally restrained rats in a novel, double-cannulated model to determine the effects of formulation on systemic blood absorption and mesenteric lymph transport of ontazolast. The bioavailability of ontazolast was significantly and substantially enhanced by all of the lipid-based formulations. While these formulations also significantly increased the amount of ontazolast transported by the lymph, the total amounts transported were insufficient to account for the improvement in bioavailability, which may be due to the elimination or reduction of the barriers of poor aqueous solubility and slow dissolution to absorption of ontazolast from the gastrointestinal tract, or the effects of lipid on the gastrointestinal membrane permeability, transit time, or metabolism of ontazolast.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (149.06 mM)
关键字: Ontazolast | BIRM270 | BIRM 270
相关产品: YM 16638 | Linetastine | hnps-PLA Inhibitor | Montelukast | LTβR-IN-1 | CP-105696 | MCI826 | Moxilubant | DW-1350 | Darbufelone mesylate
相关库: Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途