培美酸 T68126
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 114716-16-4 | ¥5,220.00 | 询底价 |
25 mg | 114716-16-4 | ¥3,620.00 | 询底价 |
1 mg | 114716-16-4 | ¥600.00 | 询底价 |
5 mg | 114716-16-4 | ¥1,430.00 | 询底价 |
100 mg | 114716-16-4 | ¥7,380.00 | 询底价 |
10 mg | 114716-16-4 | ¥2,130.00 | 询底价 |
500 mg | 114716-16-4 | ¥14,700.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pemedolac
描述: Pemedolac (Dexpemedolac)是一种小分子 COX 抑制剂,可作为一种新型长效非麻醉性镇痛化合物,可用于治疗神经系统疾病、皮肤和肌肉骨骼疾病。
体内活性: Pemedolac exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. In each of the animal models used the analgesic potency of pemedolac was defined by an ED50 of 2.0 mg/kg p.o. or less. Significant analgesic activity was detected in rats at 16 hr after administration of 1 mg/kg p.o. (paw pressure test) and at 10 hr after administration of 10 mg/kg p.o. to mice (p-phenylbenzoquinone writhing). Inasmuch as pemedolac was inactive in the hot plate and tail-flick tests; and its analgesic activity was not antagonized by naloxone (1 mg/kg s.c.), and tolerance did not develop upon multiple administrations; this drug does not exert its analgesic effects through an opiate mechanism. Pemedolac differed from standard nonsteroidal anti-inflammatory drugs (NSAIDs) in that the doses that produced analgesia were much lower than those required for either anti-inflammatory or gastric irritant effects. In acute anti-inflammatory tests, pemedolac exhibited only weak activity as evidenced by an ED50 of approximately 100 mg/kg p.o. in the carrageenan paw edema procedure. This demonstrates for pemedolac a separation of at least 50-fold between the acute analgesic and anti-inflammatory activities, which was greater than that observed with reference NSAIDs.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (143.09 mM)
关键字: Pemedolac
相关产品: Chlorotrianisene | Xanthohumol | ETHYL CAFFEATE | Eupatolide | Felbinac | Lumiracoxib | Hamaudol | PTUPB | Penduletin | Asaraldehyde
相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途