二丙维林盐酸盐 T68853
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 69373-88-2 | ¥2,900.00 | 询底价 |
50 mg | 69373-88-2 | ¥9,270.00 | 询底价 |
500 mg | 69373-88-2 | ¥24,800.00 | 询底价 |
10 mg | 69373-88-2 | ¥4,290.00 | 询底价 |
25 mg | 69373-88-2 | ¥6,850.00 | 询底价 |
100 mg | 69373-88-2 | ¥12,500.00 | 询底价 |
1 mg | 69373-88-2 | ¥1,300.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Diproteverine HCl
描述: Diproteverine HCl 是具有抗心绞痛特性的新型钙拮抗剂,具有解痉活性和血管活性。
体外活性: Diproteverine (1 μM; sheep Purkinje fibers) to reduce the amplitude of the slow action potential (IC30 = 2 μM) and to shorten the duration of the fast action potential at 50% repolarisation (IC30 = 2.5 μM). Papaverine was found to possess marginal membrane channel-blocking activity and to be much more potent than diproteverine as a cAMP-phosphodiesterase inhibitor (IC50 = 8 μM).[2]
体内活性: Diproteverine (0.25-0.75 mg/kg; i.e.; dog; at plasma levels within the assumed therapeutic range) dose-relatedly decreases heart rate, increases corrected sinus node recovery time, and decreases Wenckebach point. These effects are observed at plasma levels ranging between 16.2 +/- 4.1 and 144.7 +/- 12.5 ng/ml. After cholinergic blockade with N-methylscopolammonium, diproteverine lowers heart rate (greater than or equal to 0.25 mg/kg), increases corrected sinus node recovery time, and decreases Wenckebach point (greater than or equal to 0.5 mg/kg). After propranolol, diproteverine only significantly reduces corrected sinus node recovery time 5 min after the third administration (0.75 mg/kg). After pharmacologic autonomic blockade by N-methylscopolammonium propranolol combination, diproteverine lowers the intrinsic heart rate (greater than or equal to 0.25 mg/kg) and Wenckebach point (greater than or equal to 0.5 mg/kg). Diproteverine does not modify mean blood pressure. These results show that diproteverine administered with and without pharmacologic autonomic blockade in the conscious dog causes dose-related depressant effects on sinus node function and atrioventricular conduction without producing significant vasodilatation.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (119.04 mM)
关键字: Diproteverine HCl | Diproteverine hydrochloride
相关产品: Myoregulin | Butamben | FS-2 | Calcium Channel antagonist 2 | Catharanthine | Cis-22a | Levamlodipine besylate | 5J-4 | Bepridil hydrochloride | D-myo-Inositol-1,4,5-triphosphate trisodium
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途