化合物 MRK003 T68980
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 623165-93-5 | ¥29,500.00 | 询底价 |
25 mg | 623165-93-5 | ¥17,200.00 | 询底价 |
50 mg | 623165-93-5 | ¥22,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MRK003
描述: MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cells. In addition, MRK003 caused an upregulation of pAkt, indicating crosstalk with the PI3K/Akt pathway.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MRK003 | MRK 003 | MRK-003. | MRK-003
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途