化合物N6022 T6901

Product Introduction
Bioactivity


英文名: N6022

描述: N6022 是选择性可逆的S-Nitrosoglutathione reductase 抑制剂，IC50=8 nM。

细胞实验: N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis.

体外活性: N6022 binds to rat plasma proteins in a concentration-dependent manner. At lower drug concentrations (20 μM), N6022 show more effect on ATP than on GSH. N6022 (IC50 of 8 nM and a Ki of 2.5 nM) binds in the GSNO substrate binding pocket like a competitive inhibitor. N6022 is uncompetitive with cofactors NAD+ and NADH.

体内活性: N6022以50 mg/kg的剂量处理大鼠，导致肉芽肿发生率略有增加。在血清中，N6022的溶解浓度可达5 mg/mL。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (108.58 mM)


关键字: Inhibitor | N-6022 | N6022 | N 6022 | inhibit | S-nitrosoglutathione reductase | GSNOR

相关产品: Cavosonstat

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途