制霉菌素 A3 T6913

Product Introduction
Bioactivity


英文名: Nystatin A3

描述: Nystatin A3 (Fungicidin) 是从Streptomyces noursei 中产生的一种多烯类抗真菌药，用作治疗口咽念珠菌病的外用剂。

体外活性: Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six?Candida?species. [1] Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. [2] Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of?endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. [3]

体内活性: Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. [3] Liposomal?Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. [4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : <1 mg/mL
H2O : <1 mg/mL
DMSO : 16 mg/mL (15.1 mM)


关键字: Fungal | Inhibitor | Nystatin A 3 | inhibit | Nystatin A3 | Antibiotic | Nystatin A-3

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途