肌氨酸 T6975

Product Introduction
Bioactivity


英文名: Sarcosine

描述: Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂，通过增加甘氨酸的浓度增强 NMDA 受体的功能，可用于精神分裂症的研究。

细胞实验: Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)

体外活性: Sarcosine 作为GlyR激动剂以及GlyT1抑制剂和NMDAR共激动剂发挥作用，但其作为GlyR激动剂的效力较甘氨酸为低，且不是完全激动剂[1]。经Sarcosine处理的细胞活性显著降低[4]。

体内活性: Sarcosine表现出弱抗癫痫特性[2]。在mGluR5基因敲除小鼠中，它能改善(prepulse inhibition)PPI缺陷[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble
H2O : 10 mM


关键字: inhibit | dysfunction | schizophrenia | Endogenous Metabolite | Inhibitor | Sarcosine | cognitive | depression | GlyT | Glycine transporters

相关产品: Opiranserin hydrochloride | Bitopertin | Bitopertin (R enantiomer) | PF-03463275 | Tilapertin | Amoxapine | Opiranserin | Org 25543 hydrochloride | ALX-1393 | ASP2535

相关库: Anti-Neurodegenerative Disease Compound Library | Human Endogenous Metabolite Library | Drug Repurposing Compound Library | ReFRAME Related Library | Glutamine Metabolism Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | Human Endogenous Metabolite Compound Library Plus | Target-Focused Phenotypic Screening Library | Bioactive Compound Library

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