化合物SKL2001 T6989

Product Introduction
Bioactivity


英文名: SKL2001

描述: SKL2001 是一种Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤作用。它能够破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。

细胞实验: The HEK293 reporter and control cell lines were established. The HEK293 reporter cells were inoculated into 384-well plates at 10 000 cells per well and grown for 24 h. Next, each compound in the chemical library (～270 000) was added to at a final concentration of 20 μM. After 15 h, the plates were assayed for firefly luciferase activity.(Only for Reference)

体外活性: SKL2001 upregulated β-catenin responsive transcription by increasing the intracellular β-catenin protein level and inhibited the phosphorylation of β-catenin at residues Ser33/37/Thr41 and Ser45, which would mark it for proteasomal degradation, without affecting CK1 and GSK-3β enzyme activities. SKL2001 disrupted the Axin/β-catenin interaction, which is a critical step for CK1- and GSK-3β-mediated phosphorylation of β-catenin at Ser33/37/Thr41 and Ser45. The treatment of mesenchymal stem cells with SKL2001 promoted osteoblastogenesis and suppressed adipocyte differentiation, both of which were accompanied by the activation of Wnt/β-catenin pathway. SKL2001 did not affect either NF-κB or p53 reporter activity and inhibits β-catenin phosphorylation without affecting GSK-3β activity[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 53 mg/mL (185.1 mM)
Ethanol : 53 mg/mL (185.1 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: SKL2001 | Inhibitor | Wnt | Beta catenin | β-catenin | SKL-2001 | inhibit | SKL 2001

相关产品: TNIK-IN-2 | PARP1/2/TNKS1/2-IN-1 | Wnt/β-catenin agonist 4 | LF3 | KY-05009 | DK419 | iCRT-5 | TINK-IN-1 | Bisdemethoxycurcumin | Specnuezhenide

相关库: Anti-Aging Compound Library | Anti-Prostate Cancer Compound Library | Neuronal Differentiation Compound Library | Cancer Cell Differentiation Compound Library | Anti-Ovarian Cancer Compound Library | CNS-Penetrant Compound Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Anti-Fibrosis Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途