化合物 MFH290 T69931
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 2088715-91-5 | ¥19,500.00 | 询底价 |
50 mg | 2088715-91-5 | ¥15,300.00 | 询底价 |
25 mg | 2088715-91-5 | ¥11,700.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MFH290
描述: MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MFH-290 | OAT1441 | MFH290 | OAT-1441 | MFH 290
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途