化合物 INCB059872 tosylate T69937

Product Introduction
Bioactivity


英文名: INCB059872 tosylate

描述: INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: INCB-059872 Tosylate | F13640 Fumarate | F 13640 Fumarate | INCB 059872 Tosylate | F-13640 Fumarate | INCB059872 Tosylate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途