化合物 NLG802 HCl T69944
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2071684-09-6 | ¥10,600.00 | 询底价 |
100 mg | 2071684-09-6 | ¥17,500.00 | 询底价 |
50 mg | 2071684-09-6 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NLG802 HCl
描述: NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MPT0L-145 | MPT0L 145 | NLG802 HCl
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途