原花青素 B2 T6S1367

Product Introduction
Bioactivity


英文名: Procyanidin B2

描述: Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质，具有抗肿瘤，抗氧化等活性。

动物实验: Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2].

体外活性: Procyanidin B2 通过与 H2O2 和金属离子的相互作用, 表现出抗氧化和促氧化的特性[1]。

体内活性: 肉桂中的Procyanidin B2抑制了糖尿病大鼠肾脏中AGEs的积累，并改善了AGEs介导的DN[2]的病理过程。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (86.43 mM)


关键字: inhibit | Proanthocyanidin B 2 | Procyanidin B 2 | Inhibitor | Proanthocyanidin B-2 | Reactive Oxygen Species | Procyanidin B2 | Procyanidin B-2

相关产品: Glabridin | Sodium Thiocyanate | Schisandrin B | Methylprednisolone Acetate | Lipoic acid | Pinocembrin | Mesotrione | Chlorogenic Acid | Canthaxanthin | (20S)-Protopanaxadiol

相关库: Pyroptosis Compound Library | Tobacco Monomer Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Anti-Fibrosis Compound Library | Miao medicine Compound Library | Food as Medicine Compound Library | Traditional Mongolian Medicine Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途