化合物 Pimodivir tosylate T70207
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1777814-27-3 | ¥18,300.00 | 询底价 |
25 mg | 1777814-27-3 | ¥13,900.00 | 询底价 |
100 mg | 1777814-27-3 | ¥23,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pimodivir tosylate
描述: Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay, with a similar EC50 in a viral RNA replication assay. VX-787 is active against a diverse panel of influenza A virus strains, including H1N1pdm09 and H5N1 strains, as well as strains with reduced susceptibility to neuraminidase inhibitors (NAIs).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Pimodivir Tosylate | SB1B57 | SB 1B57
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途