化合物 Indoxyl Sulfate-d5 potassium salt T70313
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 1644451-34-2 | ¥17,500.00 | 询底价 |
25 mg | 1644451-34-2 | ¥9,850.00 | 询底价 |
50 mg | 1644451-34-2 | ¥12,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Indoxyl Sulfate-d5 potassium salt
描述: Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: GW297361X | GW-297361X | Indoxyl Sulfate-d5 potassium | GW589933X | GW 297361X | GW 589933X
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