化合物 Mevidalen HBA T70326

Product Introduction
Bioactivity


英文名: Mevidalen HBA

描述: Mevidalen, also known as LY3154207, is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM). In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia..

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: OD-38 | OD 38 | Mevidalen HBA

化合物 Mevidalen HBA T70326信息由TargetMol中国为您提供，如您想了解更多关于化合物 Mevidalen HBA T70326报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途