酪胺盐酸盐 T7091

Product Introduction
Bioactivity


英文名: N-Formyl-Met-Leu-Phe

描述: N-Formyl-Met-Leu-Phe (N-Formyl-MLF) 是一种趋化肽和N-甲酰基肽受体的特异性配体，可抑制TNF-alpha 的分泌。

动物实验: ebrafish (Danio rerio) embryos were collected from spontaneous spawnings reared at 28.5 ℃. Three days postfertilization (～1 day after hatching), feeding of the commercial powder for baby fish was started. Zebrafish embryos were stimulated with fMLP from 8 to 48 h postfertilization (hpf), washed, and raised at 28.5 ℃. At 5 days postfertilization (dpf), 20 zebrafish were stained with Alizarin Red for examination of the effect of fMLP on bone formation. Zebrafish were fixed in 4% paraformaldehyde for 12–18 h. Following fixation, fish were depigmented overnight in 1% KOH containing 3% H2O2 and immersed for 2 h in 0.5% KOH containing 0.05% Alizarin Red, pH 4.2. Alizarin-stained fish were then cleared again in 1% KOH and observed under a microscope[2].

体外活性: N-Formyl-Met-Leu-Phe 受体与 Ni GTP 调节蛋白相关联，N-Formyl-Met-Leu-Phe 复合物在控制多个中性粒细胞功能方面具有重要作用[1]。

体内活性: N-Formyl-Met-Leu-Phe(fMLP)在斑马鱼和兔子中促进了骨骼形成，表明其在体内具有生理学相关性[2]。

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 82.5 mg/mL (188.55 mM)


关键字: N-Formyl-Met-Leu-Phe | TNF Receptor | TNFR | Inhibitor | NFormylMetLeuPhe | Tumor Necrosis Factor Receptor | inhibit | N Formyl Met Leu Phe

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相关库: Cytokine Inhibitor Library | Immuno-Oncology Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Peptide Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途