化合物 Netarsudil free base T71119

Product Introduction
Bioactivity


英文名: Netarsudil free base

描述: Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and​/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Netarsudil | Netarsudil free base | ABI 274 | ABI274

化合物 Netarsudil free base T71119信息由TargetMol中国为您提供，如您想了解更多关于化合物 Netarsudil free base T71119报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途