化合物 PBT434 HBr T71174
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1232841-78-9 | ¥16,800.00 | 询底价 |
100 mg | 1232841-78-9 | ¥21,500.00 | 询底价 |
25 mg | 1232841-78-9 | ¥12,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PBT434 HBr
描述: PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: PBT434 HBr | SK&F-106615-I-2 | SK&F-106615-A-2 | SK&F-106615I2 | SK&F106615A2 | SKF 106615SKF 106615SKF106615
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途