化合物 LGB-321 HCl T71227
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 1210416-93-5 | ¥33,500.00 | 询底价 |
50 mg | 1210416-93-5 | ¥25,800.00 | 询底价 |
25 mg | 1210416-93-5 | ¥19,400.00 | 询底价 |
Product Introduction
Bioactivity
英文名: LGB-321 HCl
描述: LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cell NHL. In vivo, LGB-321 is orally available, demonstrates efficacy in tumor xenografts and is well-tolerated within the therapeutic exposure range in mice. (source: Clin Cancer Res. 2014 Apr 1;20(7):1834-45 )
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: NA-0346 | NA0346 | LGB-321 HCl
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途