交沙霉素 T7148
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 16846-24-5 | ¥258.00 | 询底价 |
500 mg | 16846-24-5 | ¥3,380.00 | 询底价 |
1 mL | 16846-24-5 | ¥357.00 | 询底价 |
100 mg | 16846-24-5 | ¥1,350.00 | 询底价 |
50 mg | 16846-24-5 | ¥756.00 | 询底价 |
25 mg | 16846-24-5 | ¥413.00 | 询底价 |
Product Introduction
Bioactivity
英文名: JOSAMYCIN
描述: Josamycin (EN-141) 是一种大环内酯类抗生素,对多种病原体有抗菌活性。它对核糖体的解离常数Kd 为 5.5 nM。
细胞实验: LPS was purified by employing phenol-water extraction protocol. Culture supernatants were analyzed for nitric oxide (NO) and interleukin (IL)-1β. Real-time PCR and immunoblotting were conducted to quantify mRNA and protein expression, respectively. The expression levels of IL-1β were analyzed by confocal laser scanning microscopy. NF-κB-dependent SEAP levels were estimated by reporter assay[1].
动物实验: Topical treatment with josamycin significantly suppressed the increase in the skin severity score in NC/Nga mice. This suppressive effect was equal to that of betamethasone, and was associated with a decrease in the density of cellular infiltration into the dermis, the mast cell count in the dermis and the serum IgE level. Furthermore, topical application of josamycin reduced the expression of IFN-γ and IL-4 in auricular lymph node cells and the skin lesions[2].
体外活性: Josamycin significantly attenuated NO production elicited by P. intermedia LPS as well as induction of iNOS protein and mRNA in RAW264.7 cells. While the release of IL-1β from cells stimulated by LPS was suppressed in the presence of josamycin, josamycin failed to reduce the degree of IL-1β mRNA expression. Josamycin did not reduce the stability of IL-1β mRNA induced by P. intermedia LPS, at the same time josamycin also failed to suppress the LPS-induced intracellular IL-1β expression. Josamycin augmented HO-1 induction in cells exposed to P. intermedia LPS, and SnPP, an inhibitor of HO-1 activity, reversed the suppressive impact of josamycin upon NO generation induced by LPS. Josamycin diminished NF-κB transcriptional activity induced by P. intermedia LPS. Further, josamycin enhanced SOCS1 mRNA level in cells activated with LPS[1].
体内活性: Josamycin (0.1%) was topically administered to NC/Nga mice with AD-like skin lesions induced by 2, 4, 6-trinitrochlorobenzene (TNCB). The therapeutic effects of josamycin were assessed by measurement of the skin severity scores, histological changes in the lesioned skin, serum levels of total IgE, and expression of interferon (IFN)-γ and interleukin (IL)-4 in lymph nodes and skin lesions[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 41.67 mg/mL (50.33 mM)
关键字: inhibit | EN141 | EN 141 | JOSAMYCIN | Inhibitor | Antibiotic | Bacterial
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相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | Drug-induced Liver Injury (DILI) Compound Library | Covalent Natural Product Library | Human Metabolite Library | Anti-Bacterial Compound Library | Microbial Natural Product Library | NO PAINS Compound Library | Covalent Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途