雷夫康唑 T7152

Product Introduction
Bioactivity


英文名: Ravuconazole

描述: Ravuconazole (ER-30346) 是一种口服的三唑广谱抗真菌剂。

体外活性: The in vitro activity of BMS-207147 against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method.?Geometric mean MICs (in microg/ml) were as follows: 1.71 for BMS-207147, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of concentrations of each drug was 0.125 to >16 microg/ml.?Aspergillus fumigatus was significantly more susceptible to BMS-207147 (P < 0.?05) than A. terreus and A. flavus.?No BMS-207147-resistant A. fumigatus isolates were identified, though eight itraconazole-resistant (MIC, >8 microg/ml) isolates were.?BMS-207147 is active against Aspergillus spp. at slightly high concentrations compared with itraconazole and amphotericin B[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (114.29 mM)


关键字: ER 30346 | Ravuconazole | inhibit | ER30346 | BMS207147 | Fungal | Inhibitor | BMS 207147

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