化合物ZIM T72024

Product Introduction
Bioactivity


英文名: ZIM

描述: ZIM，一种从4-Aminoantipyrine衍生的降冰片烯，有效诱导DNA损伤，造成基因组及染色体损害，进而引发细胞死亡和激活吞噬。其化疗潜力适用于癌症研究。

体内活性: ZIM (i.p., 12, 24, and 48 mg/kg) effectively reduces the chromosomal micronucleus frequency at all doses in adult male Swiss mice, with a chemical preventive effect observed at 24 and 72 hours, and the range of percentage decrease in damage is between 38.36% and 83.26%.[1] ZIM (i.p., 12, 24, and 48 mg/kg) lowers the frequency of liver cell and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX. At concentrations of 12, 24, and 48 mg/kg, the percentage decrease in liver damage in the CIS group is 79.27%, 75.20%, and 52.84%, respectively, while in the DOX group, it is 62.06%, 59.44%, and 77.80%. The percentage decrease in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.0 mg/mL (128.8 mM)


关键字: ZIM

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

化合物ZIM T72024信息由TargetMol中国为您提供，如您想了解更多关于化合物ZIM T72024报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途