化合物FK 3311 T7207
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 116686-15-8 | ¥333.00 | 询底价 |
25 mg | 116686-15-8 | ¥1,480.00 | 询底价 |
100 mg | 116686-15-8 | ¥3,380.00 | 询底价 |
1 mL | 116686-15-8 | ¥729.00 | 询底价 |
1 mg | 116686-15-8 | ¥235.00 | 询底价 |
10 mg | 116686-15-8 | ¥866.00 | 询底价 |
200 mg | 116686-15-8 | ¥4,850.00 | 询底价 |
5 mg | 116686-15-8 | ¥541.00 | 询底价 |
50 mg | 116686-15-8 | ¥2,280.00 | 询底价 |
Product Introduction
Bioactivity
英文名: FK 3311
描述: FK 3311 (COX-2 Inhibitor V) 是一种细胞渗透性和口服磺胺类药物,可作为 COX-2 抑制剂和非甾体抗炎药。
动物实验: Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1].
体内活性: Survival rate was significantly better (p <0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p <0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <0.05)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (292.97 mM)
关键字: COX | Cyclooxygenase | FK3311 | Inhibitor | inhibit | FK 3311
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相关库: Anti-Prostate Cancer Compound Library | ReFRAME Related Library | Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途