BTA-EG4水合物 T72074

Product Introduction
Bioactivity


英文名: BTA-EG4 hydrate

描述: BTA-EG4 hydrate 可用于诊断、预防或减轻像阿尔茨海默病类的淀粉样蛋白相关疾病的症状，可用于改善认知功能。

体外活性: BTA-EG4 (40–60 μM ; 48 h) significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins.[1]

体内活性: BTA-EG4 (30 mg/kg ; injections ; daily ; 2 weeks) improved dendritic spine density and cognitive function of 3xTg AD mice in an age-dependent manner. BTA-EG4 injected 3xTg AD mice at 6-10 months of age showed improved learning and memory ; however, only minimal improvement was observed at 13-16 months of age. This behavioral improvement corresponds to a decrease in soluble Aβ 40 levels. These findings suggest that BTA-EG4 may be beneficial in ameliorating the synaptic loss seen in early AD.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 13.5 mg/mL

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途