沙铂 T7221

Product Introduction
Bioactivity


英文名: Satraplatin

描述: Satraplatin (BMS182751) 是一种烷化剂 ，是一种口服的抗肿瘤铂 (IV) 复合物，具有广泛的抗肿瘤效果。

细胞实验: CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].

体外活性: KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33 mg/mL (65.96 mM)


关键字: BMS 182751 | BMY-45594 | BMS-182751 | Satraplatin | BMY 45594 | DNA Alkylator/Crosslinker | JM 216 | Inhibitor | inhibit | JM-216

相关产品: Pipobroman | RITA | Lomustine | Altretamine | Carmustine | Procarbazine hydrochloride | Palifosfamide | Ifosfamide | Chlorambucil | Carboplatin

相关库: Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Lung Cancer Compound Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途