化合物GS-441524 T7222

Product Introduction
Bioactivity


英文名: GS-441524

描述: GS-441524 是 Remdesivir 的主要活性代谢物，活性更优于 Remdesivir ，治疗患有自然发生的猫传染性腹膜炎的猫。

动物实验: Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h[1].

体内活性: Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (171.66 mM)


关键字: GS-441524 | Inhibitor | feline | SARS coronavirus | virus | GS-441524 Triphosphate | GS441524 | FIPV | infectious | peritonitis | DNA/RNA Synthesis | inhibit | GS 441524 Triphosphate | GS 441524 | SARS-CoV | GS441524 Triphosphate

相关产品: SARS-CoV-2-IN-67 | SARS-CoV-2-IN-47 | Lopinavir | EIDD-1931 | Leritrelvir | GRL-0496 | SARS-CoV-2 3CLpro-IN-19 | Sivelestat | Aloxistatin | 4'-O-Methylbavachalcone

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library | Anti-Viral Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途