替诺福韦艾拉酚胺富马酸盐 T7282

Product Introduction
Bioactivity


英文名: Tenofovir alafenamide hemifumarate

描述: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。

体外活性: Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (93.54 mM)


关键字: Inhibitor | GS 7340 | Human immunodeficiency virus | Tenofovir alafenamide Fumarate | inhibit | Tenofovir alafenamide hemifumarate | GS7340 | HIV | Tenofovir alafenamide | GS-7340 | GS-7340 hemifumarate | Tenofovir alafenamide Hemifumarate | Reverse Transcriptase

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相关库: Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Orally Active Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途